Autoimmunity to Myelin Oligodendrocyte Glycoprotein in Rats Mimics the Spectrum of Multiple Sclerosis Pathology
Identifieur interne : 001210 ( Main/Exploration ); précédent : 001209; suivant : 001211Autoimmunity to Myelin Oligodendrocyte Glycoprotein in Rats Mimics the Spectrum of Multiple Sclerosis Pathology
Auteurs : Maria K. Storch [Autriche] ; Andreas Stefferl [Allemagne] ; Uschi Brehm [Allemagne] ; Robert Weissert [Suède] ; Erik Wallström [Suède] ; Martin Kerschensteiner [Allemagne] ; Tomas Olsson [Suède] ; Chris Linington [Allemagne] ; Hans Lassmann [Autriche]Source :
- Brain Pathology [ 1015-6305 ] ; 1998-10.
English descriptors
- Teeft :
- Active demyelination, Allergic encephalomyelitis, Autoimmune, Autoimmune encephalomyelitis, Autoimmunity, Axon, Bielschowsky silver impregnation, Blue myelin stain, Cerebellar, Cerebellar type, Chronic myelin oligodendrocyte glycoprotein, Clinical neurology, Degenerating myelin sheaths, Demyelinated, Demyelinating, Demyelinating antibodies, Demyelinating areas, Demyelinating diseases, Demyelinating lesions, Demyelination, Destructive lesions, Different markers, Encephalomyelitis, Environmental factors, Eosinophilic granulocytes, General neuropathology, Genetic background, Glial fibrillary acidic protein, Glycoprotein, Granulocyte, Immune reactions, Immunocytochemistry, Inflammation, Inflammatory, Lassmann, Lesion, Lesional, Lesional distribution, Luxol, Macrophage, Multiple sclerosis, Myelin, Myelin oligodendrocyte glycoprotein, Myelitis, Neuritis, Neurol, Neuromyelitis, Neuromyelitis optica, Neuropathology, Oligodendrocyte, Optic, Optic nerve, Optic nerve involvement, Optic nerves, Optic neuritis, Optic system, Optica, Periventricular, Periventricular type, Plaque, Plaque distribution, Present study, Proteolipid protein, Rat, Sclerosis, Sensitization, Significant differences, Spinal, Spinal cord, Spinal type, Storch, Subpial demyelination.
Abstract
Multiple sclerosis is a chronic inflammatory disease characterized by perivenous inflammation and focal destruction of myelin. Many attempts have been undertaken previously to create animal models of chronic inflammatory demyelinating diseases through autoimmunity or virus infection. Recently, however, a new model of myelin oligodendrocyte glycoprotein (MOG) induced autoimmune encephalomyelitis became available, which, in a very standardized and predictable way, leads to chronic (relapsing or progressive) disease and widespread CNS demyelination. In the present study we actively induced MOG‐experimental autoimmune encephalomyelitis (EAE) in different inbred rat strains using different immunization protocols. The pathology found in our models closely reflects the spectrum of multiple sclerosis (MS) pathology: Classical MS as well as variants such as optic neuritis, Devic's disease and Marburg's type of acute MS are mimicked in rats immunized with MOG antigen. Furthermore we demonstrate, that by using the proper strain/sensitization regime, subforms of MS such as for instance neuromyelitis optica can be reproducibly induced. Our study further supports the notion, that incidence and expression of the disease in this model, alike the situation in multiple sclerosis, is determined by genetic and environmental factors.
Url:
DOI: 10.1111/j.1750-3639.1998.tb00194.x
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000429
- to stream Istex, to step Curation: 000409
- to stream Istex, to step Checkpoint: 000398
- to stream Main, to step Merge: 001223
- to stream Main, to step Curation: 001210
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Autoimmunity to Myelin Oligodendrocyte Glycoprotein in Rats Mimics the Spectrum of Multiple Sclerosis Pathology</title><author><name sortKey="Storch, Maria K" sort="Storch, Maria K" uniqKey="Storch M" first="Maria K." last="Storch">Maria K. Storch</name></author><author><name sortKey="Stefferl, Andreas" sort="Stefferl, Andreas" uniqKey="Stefferl A" first="Andreas" last="Stefferl">Andreas Stefferl</name></author><author><name sortKey="Brehm, Uschi" sort="Brehm, Uschi" uniqKey="Brehm U" first="Uschi" last="Brehm">Uschi Brehm</name></author><author><name sortKey="Weissert, Robert" sort="Weissert, Robert" uniqKey="Weissert R" first="Robert" last="Weissert">Robert Weissert</name></author><author><name sortKey="Wallstrom, Erik" sort="Wallstrom, Erik" uniqKey="Wallstrom E" first="Erik" last="Wallström">Erik Wallström</name></author><author><name sortKey="Kerschensteiner, Martin" sort="Kerschensteiner, Martin" uniqKey="Kerschensteiner M" first="Martin" last="Kerschensteiner">Martin Kerschensteiner</name></author><author><name sortKey="Olsson, Tomas" sort="Olsson, Tomas" uniqKey="Olsson T" first="Tomas" last="Olsson">Tomas Olsson</name></author><author><name sortKey="Linington, Chris" sort="Linington, Chris" uniqKey="Linington C" first="Chris" last="Linington">Chris Linington</name></author><author><name sortKey="Lassmann, Hans" sort="Lassmann, Hans" uniqKey="Lassmann H" first="Hans" last="Lassmann">Hans Lassmann</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:289D82BFB5AAD1E0F90AD378A31CC4E77A71CBC7</idno><date when="1998" year="1998">1998</date><idno type="doi">10.1111/j.1750-3639.1998.tb00194.x</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-FWL8W1CK-Z/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000429</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000429</idno><idno type="wicri:Area/Istex/Curation">000409</idno><idno type="wicri:Area/Istex/Checkpoint">000398</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000398</idno><idno type="wicri:doubleKey">1015-6305:1998:Storch M:autoimmunity:to:myelin</idno><idno type="wicri:Area/Main/Merge">001223</idno><idno type="wicri:Area/Main/Curation">001210</idno><idno type="wicri:Area/Main/Exploration">001210</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Autoimmunity to Myelin Oligodendrocyte Glycoprotein in Rats Mimics the Spectrum of Multiple Sclerosis Pathology</title><author><name sortKey="Storch, Maria K" sort="Storch, Maria K" uniqKey="Storch M" first="Maria K." last="Storch">Maria K. Storch</name><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>Neurological Institute, University of Vienna, A‐1090 Vienna</wicri:regionArea><wicri:noRegion>A‐1090 Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Stefferl, Andreas" sort="Stefferl, Andreas" uniqKey="Stefferl A" first="Andreas" last="Stefferl">Andreas Stefferl</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max‐Planck‐Insitute for Neurobiology, D‐82152 Martinsried</wicri:regionArea><wicri:noRegion>82152 Martinsried</wicri:noRegion><wicri:noRegion>D‐82152 Martinsried</wicri:noRegion></affiliation></author><author><name sortKey="Brehm, Uschi" sort="Brehm, Uschi" uniqKey="Brehm U" first="Uschi" last="Brehm">Uschi Brehm</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max‐Planck‐Insitute for Neurobiology, D‐82152 Martinsried</wicri:regionArea><wicri:noRegion>82152 Martinsried</wicri:noRegion><wicri:noRegion>D‐82152 Martinsried</wicri:noRegion></affiliation></author><author><name sortKey="Weissert, Robert" sort="Weissert, Robert" uniqKey="Weissert R" first="Robert" last="Weissert">Robert Weissert</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Neuroimmunology Unit, Center of Molecular Medicine, Karolinska Hospital, S‐17176 Stockholm</wicri:regionArea><wicri:noRegion>S‐17176 Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Wallstrom, Erik" sort="Wallstrom, Erik" uniqKey="Wallstrom E" first="Erik" last="Wallström">Erik Wallström</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Neuroimmunology Unit, Center of Molecular Medicine, Karolinska Hospital, S‐17176 Stockholm</wicri:regionArea><wicri:noRegion>S‐17176 Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Kerschensteiner, Martin" sort="Kerschensteiner, Martin" uniqKey="Kerschensteiner M" first="Martin" last="Kerschensteiner">Martin Kerschensteiner</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max‐Planck‐Insitute for Neurobiology, D‐82152 Martinsried</wicri:regionArea><wicri:noRegion>82152 Martinsried</wicri:noRegion><wicri:noRegion>D‐82152 Martinsried</wicri:noRegion></affiliation></author><author><name sortKey="Olsson, Tomas" sort="Olsson, Tomas" uniqKey="Olsson T" first="Tomas" last="Olsson">Tomas Olsson</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Neuroimmunology Unit, Center of Molecular Medicine, Karolinska Hospital, S‐17176 Stockholm</wicri:regionArea><wicri:noRegion>S‐17176 Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Linington, Chris" sort="Linington, Chris" uniqKey="Linington C" first="Chris" last="Linington">Chris Linington</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max‐Planck‐Insitute for Neurobiology, D‐82152 Martinsried</wicri:regionArea><wicri:noRegion>82152 Martinsried</wicri:noRegion><wicri:noRegion>D‐82152 Martinsried</wicri:noRegion></affiliation></author><author><name sortKey="Lassmann, Hans" sort="Lassmann, Hans" uniqKey="Lassmann H" first="Hans" last="Lassmann">Hans Lassmann</name><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>Neurological Institute, University of Vienna, A‐1090 Vienna</wicri:regionArea><wicri:noRegion>A‐1090 Vienna</wicri:noRegion></affiliation><affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Brain Pathology</title><title level="j" type="alt">BRAIN PATHOLOGY</title><idno type="ISSN">1015-6305</idno><idno type="eISSN">1750-3639</idno><imprint><biblScope unit="vol">8</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="681">681</biblScope><biblScope unit="page" to="694">694</biblScope><biblScope unit="page-count">14</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1998-10">1998-10</date></imprint><idno type="ISSN">1015-6305</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1015-6305</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Active demyelination</term><term>Allergic encephalomyelitis</term><term>Autoimmune</term><term>Autoimmune encephalomyelitis</term><term>Autoimmunity</term><term>Axon</term><term>Bielschowsky silver impregnation</term><term>Blue myelin stain</term><term>Cerebellar</term><term>Cerebellar type</term><term>Chronic myelin oligodendrocyte glycoprotein</term><term>Clinical neurology</term><term>Degenerating myelin sheaths</term><term>Demyelinated</term><term>Demyelinating</term><term>Demyelinating antibodies</term><term>Demyelinating areas</term><term>Demyelinating diseases</term><term>Demyelinating lesions</term><term>Demyelination</term><term>Destructive lesions</term><term>Different markers</term><term>Encephalomyelitis</term><term>Environmental factors</term><term>Eosinophilic granulocytes</term><term>General neuropathology</term><term>Genetic background</term><term>Glial fibrillary acidic protein</term><term>Glycoprotein</term><term>Granulocyte</term><term>Immune reactions</term><term>Immunocytochemistry</term><term>Inflammation</term><term>Inflammatory</term><term>Lassmann</term><term>Lesion</term><term>Lesional</term><term>Lesional distribution</term><term>Luxol</term><term>Macrophage</term><term>Multiple sclerosis</term><term>Myelin</term><term>Myelin oligodendrocyte glycoprotein</term><term>Myelitis</term><term>Neuritis</term><term>Neurol</term><term>Neuromyelitis</term><term>Neuromyelitis optica</term><term>Neuropathology</term><term>Oligodendrocyte</term><term>Optic</term><term>Optic nerve</term><term>Optic nerve involvement</term><term>Optic nerves</term><term>Optic neuritis</term><term>Optic system</term><term>Optica</term><term>Periventricular</term><term>Periventricular type</term><term>Plaque</term><term>Plaque distribution</term><term>Present study</term><term>Proteolipid protein</term><term>Rat</term><term>Sclerosis</term><term>Sensitization</term><term>Significant differences</term><term>Spinal</term><term>Spinal cord</term><term>Spinal type</term><term>Storch</term><term>Subpial demyelination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Multiple sclerosis is a chronic inflammatory disease characterized by perivenous inflammation and focal destruction of myelin. Many attempts have been undertaken previously to create animal models of chronic inflammatory demyelinating diseases through autoimmunity or virus infection. Recently, however, a new model of myelin oligodendrocyte glycoprotein (MOG) induced autoimmune encephalomyelitis became available, which, in a very standardized and predictable way, leads to chronic (relapsing or progressive) disease and widespread CNS demyelination. In the present study we actively induced MOG‐experimental autoimmune encephalomyelitis (EAE) in different inbred rat strains using different immunization protocols. The pathology found in our models closely reflects the spectrum of multiple sclerosis (MS) pathology: Classical MS as well as variants such as optic neuritis, Devic's disease and Marburg's type of acute MS are mimicked in rats immunized with MOG antigen. Furthermore we demonstrate, that by using the proper strain/sensitization regime, subforms of MS such as for instance neuromyelitis optica can be reproducibly induced. Our study further supports the notion, that incidence and expression of the disease in this model, alike the situation in multiple sclerosis, is determined by genetic and environmental factors.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Autriche</li><li>Suède</li></country></list><tree><country name="Autriche"><noRegion><name sortKey="Storch, Maria K" sort="Storch, Maria K" uniqKey="Storch M" first="Maria K." last="Storch">Maria K. Storch</name></noRegion><name sortKey="Lassmann, Hans" sort="Lassmann, Hans" uniqKey="Lassmann H" first="Hans" last="Lassmann">Hans Lassmann</name></country><country name="Allemagne"><noRegion><name sortKey="Stefferl, Andreas" sort="Stefferl, Andreas" uniqKey="Stefferl A" first="Andreas" last="Stefferl">Andreas Stefferl</name></noRegion><name sortKey="Brehm, Uschi" sort="Brehm, Uschi" uniqKey="Brehm U" first="Uschi" last="Brehm">Uschi Brehm</name><name sortKey="Kerschensteiner, Martin" sort="Kerschensteiner, Martin" uniqKey="Kerschensteiner M" first="Martin" last="Kerschensteiner">Martin Kerschensteiner</name><name sortKey="Linington, Chris" sort="Linington, Chris" uniqKey="Linington C" first="Chris" last="Linington">Chris Linington</name></country><country name="Suède"><noRegion><name sortKey="Weissert, Robert" sort="Weissert, Robert" uniqKey="Weissert R" first="Robert" last="Weissert">Robert Weissert</name></noRegion><name sortKey="Olsson, Tomas" sort="Olsson, Tomas" uniqKey="Olsson T" first="Tomas" last="Olsson">Tomas Olsson</name><name sortKey="Wallstrom, Erik" sort="Wallstrom, Erik" uniqKey="Wallstrom E" first="Erik" last="Wallström">Erik Wallström</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001210 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001210 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:289D82BFB5AAD1E0F90AD378A31CC4E77A71CBC7
|texte= Autoimmunity to Myelin Oligodendrocyte Glycoprotein in Rats Mimics the Spectrum of Multiple Sclerosis Pathology
}}
| This area was generated with Dilib version V0.6.33. |  |